Anti-CD3, T Cell antibody produced in rabbit, whole antiserum

Code: C7930-.2ML D2-231

Application

Anti-CD3, T Cell antibody produced in rabbit has been used in:immunoblotting immunofluorescence stainingimmunohistochemistryimmunohistochemical analysis


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€438.00 EACH
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Application

Anti-CD3, T Cell antibody produced in rabbit has been used in:immunoblotting immunofluorescence stainingimmunohistochemistryimmunohistochemical analysis

Biochem/physiol Actions

CD3 is a human cell surface glycoprotein complex involved in signal transduction following binding of antigen receptor.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

CD3 is a 20kDa glycoprotein expressed on surface of all human T lymphocytes. CD3 molecule is encoded by the gene mapped to human chromosome 11q23.3. The CD3 antigen is expressed during thymopoiesis. It is also present in the majority of T-CLL and T-lymphomas and in approximately 70% of T-ALL.

Immunogen

synthetic human CD3 peptide (residues 156-168 of the CD3-ε chain) coupled to porcine thyroglobulin. Coupling was performed by a modification of the reported method.

Specificity

The antibody reacts with the proline-rich peptide sequence comprising 13 amino acids in the cytoplasmic domain of the CD3-ε chain. It detects normal, reactive and most neoplastic human T cells in routinely processed enzyme pre-digested, formalin-fixed, paraffin-embedded tissue sections. The antibody also reacts with human tissues fixed with Bouin′s solution and embedded in paraffin. Frozen sections and smears are also suitable for staining with this antibody. The antibody reacts with T cell areas in lymphoid tissues derived from various species.

antibody formwhole antiserum
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
conjugateunconjugated
contains15 mM sodium azide
Gene Informationhuman ... CD3E(916)mouse ... Cd3e(12501)rat ... Cd3e(315609)
mol wtantigen 20 kDa (bovine and swine)
Quality Level200
shipped indry ice
species reactivitypig, canine, human, mouse, feline, bovine, sheep, chicken, Psammomys (sand rat), rat
storage temp.−20°C
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using enzyme pre-digested, formalin-fixed, paraffin-embedded human tonsil sections, western blot: 1:200 using mouse thymus extract
UniProt accession no.P07766
This product has met the following criteria to qualify for the following awards:



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